Periods of former use had a similar risk between youth with an exposure history to methylphenidate or amphetamine.ĬONCLUSION: Exposure to methylphenidate and amphetamines salts showed similar risk for cardiac ED visits. In organic chemistry, amphetamine is an excellent chiral ligand for the stereoselective synthesis of 1,1'-bi-2-naphthol. This greatly reduces the risk of potential hazards and harm if the medication is taken as prescribed, though it does still bear a strong possibility of mental. Though Adderall is an amphetamine, the actual dosage amphetamine dosage is relatively low, particularly when compared with recreational drugs. Amphetamine is also the parent compound of its own structural class, which includes a number of psychoactive derivatives. Adderall is also prescribed for narcolepsy. After adjustment for differences in covariates, the risk for cardiac ED visits was similar among current users of methylphenidate or amphetamines. Dextroamphetamine sulfate is the most common enantiopure salt.
RESULTS: A total of 456 youth visited the ED for cardiac reasons during 52783 years of follow-up. Risk between current users of methylphenidate versus amphetamine salts and former users of drugs in these categories was compared by using a time-dependent Cox proportional hazard model that adjusted for differences in gender race age year of the index date disability congenital anomalies history of circulatory disease history of hospital admission and use of antidepressants, antipsychotics, and bronchodilators. We defined cardiac events as first emergency department (ED) visit for cardiac disease or symptoms. Each month of follow-up was classified according to stimulant use into current use or former use. The analysis included all beneficiaries who were between 3 and 20 years of age, enrolled between July 1994 and June 2004, had at least 1 physician diagnosis of ADHD and were newly started on methylphenidate or amphetamine salts. Adderall and Mydayis are trade names for a combination drug called mixed amphetamine salts containing four salts of amphetamine. METHODS: A retrospective cohort design using claims data from the Florida Medicaid fee-for-service program representing a total of 2131953 children and adolescents was used. This study aimed to compare the risk for cardiac events in users of methylphenidate and amphetamine salts. OBJECTIVES: Safety concerns about central nervous system stimulants for the treatment of attention-deficit/hyperactivity disorder (ADHD) include adverse cardiac effects.
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